PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia

M Kandel; TM Macdonald; SP Walker; C Cluver; L Bergman; J Myers; R Hastie; E Keenan; NJ Hannan; P Cannon; TV Nguyen; N Pritchard; S Tong; TJ Kaitu’u-Lino

Journal article

PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia

M Kandel, TM Macdonald, SP Walker, C Cluver, L Bergman, J Myers, R Hastie, E Keenan, NJ Hannan, P Cannon, TV Nguyen, N Pritchard, S Tong, TJ Kaitu’u-Lino

Journal of the American Heart Association | WILEY | Published : 2022

DOI: 10.1161/JAHA.121.024536

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Abstract

BACKGROUND: Preeclampsia is pregnancy specific, involving significant maternal endothelial dysfunction. Predictive biomark- ers are lacking. We evaluated the biomarker potential, expression, and function of PSG7 (pregnancy-specific β-1 glycoprotein 7) and PSG9 (pregnancy-specific β-1 glycoprotein 9) in preeclampsia. METHODS AND RESULTS: At 36 weeks gestation preceding term preeclampsia diagnosis, PSG7 and PSG9 (in Australian cohorts of n=918 and n=979, respectively) were significantly increased before the onset of term preeclampsia (PSG7, P=0.013; PSG9, P=0.0011). In samples collected at 28 to 32 weeks from those with preexisting cardiovascular disease and at high risk of preec- lampsia (Man..

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University of Melbourne Researchers

Teresa MacDonald Author

Susan Walker Author

Roxanne Hastie Author

Emerson Keenan Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Funding for this work was provided by the National Health and Medical Research Council (1065854, 1183854, 116071, 2000732), the Norman Beischer Medical Research Foundation, Australian Government Research Training Program Scholarship, and the Royal Australian and New Zealand College of Obstetricians and Gynaecologists Taylor Hammond Scholarship to Dr MacDonald and National Health and Medical Research Council fellowships to Prof Kaitu'u--Lino (1159261), Prof Hannan (1146128), and Prof Tong (1136418). The funders played no role in study design or analysis.